Table 1.
Cardiac morphology, haemodynamics and serum lithium concentrations at the end of the study
| Sham | Infarction treated with | |||
|---|---|---|---|---|
| Parameters | Saline | LiCl | Saline | LiCl |
| Number of rats | 10 | 10 | 11 | 12 |
| BW, g | 418 ± 11 | 355 ± 17* | 410 ± 13 | 328 ± 18† |
| Heart rate, bpm | 393 ± 15 | 407 ± 14 | 410 ± 20 | 404 ± 16 |
| LVESP, mm Hg | 104 ± 5 | 105 ± 5 | 97 ± 8 | 96 ± 7 |
| LVEDP, mm Hg | 5 ± 2 | 5 ± 2 | 20 ± 6* | 18 ± 6* |
| +dp/dt, mm Hg/s | 7831 ± 285 | 7918 ± 312 | 2382 ± 265* | 3182 ± 259*† |
| –dp/dt, mm Hg/s | 6723 ± 302 | 6982 ± 267 | 2281 ± 287* | 2871 ± 254*† |
| Infarct size, % | … | … | 40 ± 3 | 41 ± 3 |
| LVW/tibia, mg/cm | 242 ± 20 | 245 ± 19 | 297 ± 21* | 286 ± 22* |
| RVW/tibia, mg/cm | 67 ± 12 | 62 ± 14 | 92 ± 14* | 89 ± 15* |
| LungW/tibia, mg/cm | 392 ± 31 | 381 ± 35 | 498 ± 32* | 450 ± 29*† |
| Li, mM | … | 0.35 ± 0.05 | … | 0.39 ± 0.06 |
Values are mean ± S.D. LVW, left ventricular weight; RVW, right ventricular weight. *P<0.05 compared with respective sham; †P<0.05 compared with saline-treated infarcted group.