TABLE 7.
Scoring system used for specific cellular immunostaining
| Score | Interpretation for the indicated marker(s)a |
|||
|---|---|---|---|---|
| CD2, CD3, CD4, CD5, CD8, CD18, CD163, CD172a, CD204, Iba-1, MHC-II, and calprotectin/L1 (no. of cells) | CD21 (no. of foci) | CD25 (no. of cells) | CD83 and CD86 (no. of cells) | |
| − | None | None | None | None |
| +/− | Rare | Rare | Rare | Rare |
| + | ≤200 | 1 | ≤30 | ≤80 |
| ++ | 201–350 | 2 | 31–80 | 81–120 |
| +++ | 351–500 | 3–4 | 81–200 | 121–150 |
| ++++ | >500 | >4 | >200 | >150 |
a
Numerical values express the cumulative number of immunohistochemically positive cells, except as noted, in five ×100 microscopic fields.