TABLE 3.
Replication capacities of recombinant viruses encoding patient-derived Gag/Gag-proteases of different subtypes in GXR cells
| Subtype of Gag/Gag-proteasea | RC in NL4-3 backboneb | RC in pZM246-F10 backbonec |
|---|---|---|
| A | 0.66 | NDd |
| B | 0.99 | 1.05 |
| B (NL4-3) | 1 | 1 |
| C | 0.62 | 0.51 |
| D | 0.97 | 0.60 |
| AD recombinant | 1.08 | 0.90 |
a
Patient-derived Gag proteins and Gag-proteases of different subtypes as well as the laboratory strain NL4-3.
b
RCs of NL4-3 (subtype B) recombinant viruses encoding patient-derived Gag-proteases of different subtypes were normalized to wild-type NL4-3.
c
RCs of pZM246-F10 (subtype C) recombinant viruses encoding patient-derived Gags of different subtypes were normalized to NL4-3 Gag pZM246-F10.
d
ND, not determined: two independent attempts to generate pZM246-F10 recombinant viruses encoding the patient-derived A Gag failed, and thus RC could not be assessed.