TABLE 4.
Amino acids (observed 5 or more times) in Gag associated with altered Gag-protease-mediated replication capacity in subtype A
| Codon no.a | AAb | Consensus | Function (%)c |
No. of samplesd |
P value | q value | ||
|---|---|---|---|---|---|---|---|---|
| +AA | −AA | +AA | −AA | |||||
| 75 | I | L | 65 | 70 | 13 | 40 | 0.07 | 0.04 |
| 107 | L | I | 64 | 69 | 9 | 43 | 0.007 | 0.03 |
| 125 | S | S | 70 | 65 | 37 | 15 | 0.02 | 0.03 |
| 126 | S | S | 69 | 62 | 47 | 8 | 0.01 | 0.03 |
| 315 | N | N | 67 | 71 | 18 | 36 | 0.05 | 0.04 |
| 499 | S | S | 70 | 62 | 48 | 6 | 0.03 | 0.04 |
a
According to HXB2 numbering.
b
AA, amino acid variant associated with differences in replication capacity.
c
Median replication capacity (expressed as a percentage of wild-type NL4-3) of viruses with (+AA) and without (−AA) the amino acid variant.
d
Number of sequences with (+AA) and without (−AA) the amino acid variant. Amino acid totals vary, as gaps in the alignment are considered missing data.