FIG 5.

Revertant viruses reduce cell migration and cytokine/chemokine levels. Shown are the percentages and absolute numbers of Ly6G⁺ CD11b⁺ neutrophils (N) (A and B), CD11c⁺ MHCII⁺ DCs (C and D), NKp46⁺ CD3⁻ NK cells (E and F), CD19⁺ B cells (B) (G), F4/80^low CD11b^low monocytes (M) (H), CD4⁺ CD3⁺ T cells (CD4) (I) and CD8⁺ CD3⁺ T cells (CD8) (J) in the peritoneal cavity of BALB/c mice at 6 h postinjection of 10⁷ PFU of NYVAC-C triple-deletion mutants and revertant viruses. (K to N) Concentrations of IL-6 (K), CCL2 (L), CXCL2 (M), and CXCL1 (N) in the peritoneal cavity of infected mice. Data are representative of two independent experiments. Graphs show the mean ± SEM; each point represents an individual mouse. *, P < 0.05; **, P < 0.01; ***, P < 0.001.