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. 2017 Jan 15;2(1):e584. doi: 10.1097/PR9.0000000000000584

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Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Basal nociception and postoperative thermal and mechanical hypersensitivity levels in adult and aged mice. (A) Basal thermal nociception was measured as paw withdrawal latency (PWL) in seconds in 2- to 6-, 18- and 24-month-old mice (1-way ANOVA; NS nonsignificant; ****P < 0.0001; n = 61 for adults; n = 15 for 18-month-old and n = 52 for 24-month-old). (B) Basal mechanical nociception is measured as paw withdrawal threshold in grams (statistic and n are the same as for A-panel). Postoperative thermal (C) and mechanical (D) hypersensitivity at 1 day after incision in 2- to 6-, 18- and 24-month-old mice (1-way ANOVA; NS nonsignificant; n = 48 for adults; n = 12 for 18-month-old and n = 45 for 24-month-old). Mouse ages are indicated below x-axis. Approximate baseline nociception levels (thermal on panel C and mechanical on panel D) are indicated as dashed lines and marker “Baseline.”