Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jan 15;2(1):e584. doi: 10.1097/PR9.0000000000000584

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

PMC Copyright notice

Figure 5. — Effects of locally (at surgical site) administrated buprenorphine on postoperative hypersensitivity in adult and aged mice. Incision-induced thermal (A) and mechanical (B) hypersensitivity were generated in adult and aged mice. At 1 day (for adults) and 1 to 3 days (for aged) postsurgery, operated hind paws were injected with different dosages of buprenorphine, and thermal (A) and mechanical (B) hypersensitivity were measured at 30 and 120 minutes after buprenorphine injection. Data are presented as area under the curve (AUC). Significance within age groups for buprenorphine-produced antihypersensitivity was compared against vehicle treatment (1-way ANOVA; *P < 0.05; **P < 0.01; ****P < 0.0001; n = 5–8). Significance between age groups was assessed by 2-way ANOVA. Buprenorphine dosages are indicated below log x-axis. Veh is vehicle treated conditions. Mouse ages are indicated.