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Effects of contralateral injection of buprenorphine on postoperative hypersensitivity in adult and aged mice. Thermal (A) and mechanical (B) postoperative antihypersensitivity produced at 2 hours after injection of 0.1 μg buprenorphine in operated (ipsi) or intact (contra) hind paws of adult mice. Readings were made from surgery affected hind paws (1-way ANOVA; NS, nonspecific; **P < 0.05; ***P < 0.001; ****P < 0.0001; n = 5–6).
