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. 2017 Jan 15;2(1):e584. doi: 10.1097/PR9.0000000000000584

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Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 8. — Effect of spinally and systemically injected DAMGO on surgery-induced exploratory locomotor activity in adult and aged mice: Reversal effects of DAMGO on incision-induced ambulatory behavior in adult (A) and aged mice (B). The ambulatory counts are shown on naive animals (column 1) and naive animals injected spinally with 5 ìg DAMGO (column 2). For incision surgery (POP), the ambulatory counts are shown 1 day after surgical intervention (column 3), after spinal injection of 5 ìg DAMGO (column DAMGO-Sp) or after intraperitoneal injection of DAMGO (1 mg/kg; column DAMGO-IP). Locomotor activities were measured on individual animals for a 2 hours period. Statistic is 1-way ANOVA; NS, nonsignificant; *P < 0.05; ***P < 0.001 and ****P < 0.0001.