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. Author manuscript; available in PMC: 2017 Jun 13.
Published in final edited form as: Alzheimers Dement. 2015 Jun;11(6):e1–120. doi: 10.1016/j.jalz.2014.11.001

Fig. 5.

Fig. 5

Roles of biomarkers in AD drug development. Abbreviations: AD-MET, absorption, distribution, metabolism, excretion, toxicity; BBB, blood–brain barrier; POP, proof of principle. Reproduced with permission from Ref [37].