Figure 5.

Anxiety-like and spontaneous motor behavior of equally represented Tat⁺ and Tat⁻ mice crossed to Drd1a-tdTomato or Drd2-eGFP reporter mice. Given that behavior did not differ significantly as a function of the D1 or D2 reporter, analyses of Tat genotype are shown. A–C, In a light–dark transition test, Tat⁺ mice demonstrated significantly reduced latencies to exit the brightly lit chamber (A), made more transitions between the light and dark chambers (B), and demonstrated significantly greater rearing behavior (C) than did Tat⁻ control mice. D, No differences were observed on spontaneous locomotor behavior in an open field as indicated by the total distance traveled. *Significant differences between Tat⁻ and Tat⁺ mice, p < 0.05.