Table 1.
Intrinsic electrophysiological properties of D1 and D2 striatal medium spiny neurons from HIV-1 Tat+ transgenic and Tat− control mice
| D1 MSNs |
D2 MSNs |
|||
|---|---|---|---|---|
| Tat− (n = 9–10) | Tat+ (n = 10–11) | Tat− (n = 13–14) | Tat+ (n = 14) | |
| VR (mV) | −83.0 ± 0.7 | −86.7 ± 0.6 | −84.1 ± 0.7 | −84.7 ± 0.5 |
| Capacitance (pF) | 31.8 ± 4.4 | 23.2 ± 4.5 | 34.2 ± 3.9 | 32.3 ± 3.1 |
| Input resistance (MΩ) | 38.1 ± 4.3 | 40.0 ± 4.3 | 56.3 ± 6.3 | 36.7 ± 4.3* |
| Action potential threshold (mV) | −37.9 ± 1.4 | −39.7 ± 1.1 | −40.0 ± 1.1 | −41.0 ± 1.2 |
| Action potential amplitude (mV)a | 80.6 ± 2.0 | 82.0 ± 2.4 | 88.2 ± 1.9 | 85.5 ± 1.3 |
No significant differences were observed in the intrinsic properties of D1 MSNs.
*Significant main effect of Tat genotype, p < 0.05.
aAmplitude of the first action potential evoked by a 450 pA depolarizing current injection. Amplitudes were measured from action potential threshold to peak.