Table 2.
HIV-1 Tat+ and Tat− control transgenic mice were crossed to Drd1a-tdTomato or Drd2-eGFP reporter mice
| Tat− | Tat+ | |
|---|---|---|
| Light–dark transition | (n = 16) | (n = 17) |
| Time in light (s) | 242 ± 24 | 224 ± 19 |
| Open field | (n = 14) | (n = 18) |
| Velocity (cm/s) | 3.4 ± 0.2 | 3.4 ± 0.1 |
| Time mobile (s) | 1,071 ± 42 | 1,047 ± 26 |
| Time in center (s) | 167 ± 32 | 177 ± 20 |
| Rotarod (latency to fall; s) | (n = 9) | (n = 7) |
| Fixed-speed trial (10 rpm for 30 s) | 25 ± 2 | 25 ± 2 |
| Fixed-speed trial (10 rpm for 180 s) | 130 ± 14 | 127 ± 12 |
| Accelerated trial (0–20 rpm for 180 s) | 16.0 ± 0.8 | 16.6 ± 0.4 |
| Accelerated trial (0–40 rpm for 180 s) | 97 ± 5 | 94 ± 6 |
Given that behavior did not differ significantly as a function of the D1 or D2 reporter, analyses of Tat genotype are shown. Mice were assessed for anxiety-like behavior in a light–dark transition task, for exploratory behavior in an open field, and for evoked locomotion on a rotarod. No significant differences were observed.