Table 3.
Frequency distribution of TNF-α gene polymorphism in the control, OMG + TAO and OMG groups
| Locus | Allele | Control | OMG + TAO | OMG | P* | OR (95% CI)* | P† | OR (95% CI)† | P‡ | OR (95% CI)‡ |
|---|---|---|---|---|---|---|---|---|---|---|
| GG | 214 | 50 | 114 | Ref. | ||||||
| GA | 22 | 6 | 19 | 0.750 | 0.857 (0.330–2.224) | 0.145 | 0.617 (0.321–1.187) | 0.508 | 1.389 (0.523–3.687) | |
| -238G/A | AA | 0 | 0 | 1 | - | - | 0.172 | 0.178 (0.007–4.407) | 0.508 | 1.323 (0.053–33.070) |
| GA + AA | 22 | 6 | 20 | 0.750 | 0.857 (0.330–2.224) | 0.103 | 0.586 (0.307–1.119) | 0.441 | 1.462 (0.554–3.861) | |
| G | 450 | 106 | 247 | Ref. | ||||||
| A | 22 | 6 | 21 | 0.757 | 0.864 (0.3422.183) | 0.076 | 0.575 (0.310–1.067) | 0.391 | 1.502 (0.589–3.828) | |
| GG | 212 | 46 | 113 | Ref. | ||||||
| GA | 24 | 10 | 20 | 0.107 | 0.521 (0.233–1.163) | 0.166 | 0.640 (0.339–1.208) | 0.628 | 0.814 (0.354–1.873) | |
| -308G/A | AA | 0 | 0 | 1 | - | - | 0.172 | 0.178 (0.007–4.409) | 0.524 | 1.229 (0.049–30.750) |
| GA + AA | 24 | 10 | 21 | 0.107 | 0.521 (0.233–1.163) | 0.120 | 0.609 (0.325–1.142) | 0.710 | 0.855 (0.374–1.956) | |
| G | 448 | 102 | 246 | Ref. | ||||||
| A | 24 | 10 | 22 | 0.118 | 0.546 (0.253–1.178) | 0.091 | 0.599 (0.329–1.091) | 0.818 | 0.912 (0.417–1.995) | |
| CC | 170 | 46 | 96 | Ref. | ||||||
| CT | 63 | 10 | 35 | 0.156 | 1.705 (0.811–3.582) | 0.947 | 1.016 (0.627–1.648) | 0.194 | 1.677 (0.764–3.680) | |
| -857C/T | TT | 3 | 0 | 3 | 0.369 | 1.909 (0.097–37.650) | 0.484 | 0.565 (0.112–2.854) | 0.233 | 3.373 (0.171–66.710) |
| CT + TT | 66 | 10 | 38 | 0.121 | 1.786 (0.851–3.746) | 0.936 | 0.981 (0.612–1. 571) | 0.129 | 1.821 (0.834–3.974) | |
| C | 403 | 102 | 227 | Ref. | ||||||
| T | 69 | 10 | 41 | 0.114 | 1.746 (0.869–3.510) | 0.803 | 0.948 (0.623–1.442) | 0.097 | 1.842 (0.888–3.822) | |
| CC | 183 | 30 | 95 | Ref. | ||||||
| CA | 53 | 21 | 37 | 0.006 | 2.417 (1.279–4.566) | 0.233 | 0.744 (0.457–1.211) | 0.087 | 1.797 (0.915–3.530) | |
| -863C/A | AA | 0 | 5 | 2 | <0.001 | 66.180 (3.566–1228) | 0.051 | 0.104 (0.005–2.192) | 0.006 | 7.917 (1.460–42.940) |
| CA + AA | 53 | 26 | 39 | <0.001 | 2.992 (1.629–5.495) | 0.155 | 0.706 (0.436–1.143) | 0.022 | 2.111 (1.109–4.020) | |
| C | 419 | 81 | 227 | |||||||
| A | 53 | 31 | 41 | <0.001 | 3.026 (1.829–5.004) | 0.110 | 0.700 (0.452–1.086) | 0.005 | 2.119 (1.246–3.604) | |
| CC | 157 | 42 | 92 | Ref. | ||||||
| CT | 75 | 14 | 38 | 0.287 | 1.433 (0.737–2.786) | 0.542 | 1.157 (0.725–1.846) | 0.555 | 1.239 (0.607–2.529) | |
| -1031T/C | TT | 4 | 0 | 4 | 0.302 | 2.429 (0.128–46.030) | 0.453 | 0.586 (0.143–2.400) | 0.179 | 4.135 (0.218–78.610) |
| CT + TT | 79 | 14 | 42 | 0.221 | 1.510 (0.778–2.929) | 0.675 | 1.102 (0.700–1.736) | 0.382 | 1.370 (0.676–2.776) | |
| C | 389 | 98 | 222 | |||||||
| T | 83 | 14 | 46 | 0.885 | 1.030 (0.693–1.530) | 0.885 | 1.030 (0.693–1.530) | 0.256 | 1.450 (0.762–2.762) |
*, comparison between the control and OMG + TAO groups; †, comparison between the control and OMG groups; ‡, comparison between the OMG + TAO and OMG groups; Ref., reference; Control, the healthy individuals.