Table 3.
Distribution of genotype and allele frequencies of HSP70-2 and HSP70-hom SNPs in the study subjects
| SNP (n=946) | Genotype/allele | NGT (n=256) | Normoalbuminuria (n=230) | Albuminuric (micro/macro) (n=460) | Microalbuminuria (n=230) | Macroalbuminuria (n=230) |
|---|---|---|---|---|---|---|
| HSP70-2 (+1538 A/G) | AA | 49 (19.1%) | 32 (13.9%) | 75 (16.3%) | 38 (16.5%) | 37 (16.1%) |
| AG | 170 (66.4%) | 144 (62.6%) | 253 (55.0%) | 123 (53.5%) | 130 (56.5%) | |
| GG | 37 (14.5%) | 54 (23.5%) | 132 (28.7%) | 69 (30.0%) | 63 (27.4%) | |
| A | 268 (52.3%) | 208 (45.2%) | 403 (43.8%) | 199 (43.3%) | 204 (44.3%) | |
| G | 244 (47.7%) | 252 (54.8%) | 517 (56.2%) | 261 (56.7%) | 256 (55.7%) | |
| HSP70-hom (+2437 C/T) | CC | 22 (8.6%) | 34 (14.8%) | 77 (16.7%) | 36 (15.7%) | 41 (17.8%) |
| CT | 60 (23.4%) | 62 (27.0%) | 170 (37.0%) | 80 (34.8%) | 90 (39.2%) | |
| TT | 174 (68.0%) | 134 (58.2%) | 213 (46.3%) | 114 (49.5%) | 99 (43.0%) | |
| C | 104 (20.3%) | 130 (28.3%) | 324 (35.2%) | 152 (33.0%) | 172 (37.4%) | |
| T | 408 (79.7%) | 330 (71.7%) | 596 (64.8%) | 308 (67.0%) | 288 (62.6%) |
Values are numbers (percentage). NGT, subjects with normal glucose tolerance; normoalbuminuria.