Table 4a.
Association of HSP70-2 and HSP70-hom gene SNPs in relation to albuminuria using logistic regression analysis
| SNP (n=946) | Normoalbuminuria compared with Microalbuminuria | Normoalbuminuria compared with Macroalbuminuria | Normoalbuminuria compared with Albuminuria (micro + macro) | |||
|---|---|---|---|---|---|---|
| Unadjusted OR (95% CI) | Adjusted OR (95% CI)† | Unadjusted OR (95% CI) | Adjusted OR (95% CI)† | Unadjusted OR (95% CI) | Adjusted OR (95% CI)† | |
| HSP70-2 (+1538 A/G) | ||||||
| AA | Ref. | Ref. | Ref. | |||
| AG | 0.5 (0.2–1.6) | 0.5 (0.2–1.5) | 1.0 (0.3–3.4) | 0.8 (0.2–3.0) | 0.7 (0.3–1.8) | 0.6 (0.2–1.7) |
| GG | 0.9 (0.3–2.9) | 0.9 (0.3–3.0) | 1.3** (0.4–4.8) | 1.1** (0.3–4.1) | 1.5** (0.9–2.5) | 1.4** (0.9–2.4) |
| Minor ‘G’ allele | 1.1 (0.8–1.6) | – | 1.1** (0.8–1.5) | – | 1.1** (0.8–1.3) | – |
| HSP70-hom (+2437 C/T) | ||||||
| CC | Ref. | Ref. | Ref. | |||
| CT | 1.6 (0.5–4.9) | 1.5 (0.5–4.7) | 1.4 (0.5–4.0) | 1.3 (0.4–3.9) | 1.5 (0.6–3.8) | 1.4 (0.5–3.6) |
| TT | 0.9 (0.3–2.6) | 0.7 (0.2–2.1) | 0.6 (0.2–1.5) | 0.5 (0.2–1.4) | 0.5** (0.3–0.7) | 0.4** (0.2–0.7) |
| Minor ‘T’ allele | 0.7 (0.5–1.1) | – | 0.5** (0.3–0.8) | – | 0.7** (0.6–0.9) | – |
Figures in bold were significant (P<0.05).
*P<0.05; **P<0.01.
†OR adjusted for confounding factor (age, gender and BMI).