Table 2.
Subgroups | Number of cases | Number of studies | RR (95% CI) | I2 (%) | Pheterogeneity |
---|---|---|---|---|---|
All studies | 11400 | 16 | 1.08 (0.93–1.23) | 68.3 | <0.001 |
Disease type | |||||
Colon | 9235 | 17 | 1.09 (0.95–1.25) | 48.3 | 0.014 |
Rectum | 3272 | 13 | 1.17 (0.98–1.39) | 17.8 | 0.264 |
Study design | |||||
Cohort | 8387 | 11 | 0.99 (0.85–1.15) | 57.4 | 0.009 |
Case-control | 3013 | 5 | 1.40 (0.93–2.09) | 80.8 | <0.001 |
Sex | |||||
Both | 2961 | 4 | 1.16 (0.83–1.62) | 69.8 | 0.019 |
Men | 2133 | 3 | 1.23 (1.01–1.57) | 30.9 | 0.235 |
Women | 6306 | 9 | 0.99 (0.81–1.23) | 70.3 | 0.001 |
Geographic locations | |||||
America | 9465 | 12 | 1.08 (0.89–1.30) | 73.6 | <0.001 |
Asia | 644 | 2 | 0.98 (0.65–1.46) | 30.2 | 0.231 |
Europe | 1291 | 2 | 1.23 (0.91–1.64) | 31.7 | 0.226 |