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. 2017 Aug;104:15–23. doi: 10.1016/j.nbd.2017.04.014

Fig. 6.

Fig. 6

Quantitative analysis of electrophysiological properties of l-LNv clock neurons in wild type and mutant flies expressing Pdf::RFP, in both day and night conditions. (a) Analysis of resting membrane potential (RMP) values showed a significant effect of time of day (p < 0.0001) but no effect of genotype. (b) Analysis of spontaneous firing rate (SFR) values showed a significant effect of interaction between time of day and genotype (p < 0.001). PINK1B9 neurons have a higher firing rate and park25 neurons do not show a day/night difference. (c) Analysis of input resistance (Rin) found a possible, but non-significant difference depending on time of day (p = 0.066) but no effect of genotype. (d) Analysis of responses to an injected current pulse (f +40 pA) showed a significant effect of genotype (p ¡ 0.0001), with PINK1B9 mutants being more excitable. Data were analysed using two-way ANOVA and Bonferroni's multiple comparisons tests (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; error bars indicate standard deviations (SD)).