Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Extended first-generation mPBPK model for characterization of rhTNF-α plasma PK. Model includes plasma compartment (Vp), two types of tissue compartments (V1 and V2) and a kidney compartment (Vk). Distribution of rhTNF-α to tissues is assumed driven by perfusion and diffusion. Symbols are defined in Tables 2 and 3.
