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Model-fitted plasma rhTNF-α concentration versus time profiles from experimental (A) and literature reported studies in rats (B–D) (Kojima et al., 1988; Ferraiolo et al., 1989; Zahn and Greischel, 1989). Symbols are observed concentrations and lines depict model fittings using parameters from Tables 3 and 4. The dotted line indicates the lower limit of assay quantification.
