Fig. 5.

Model-fitted rhTNF-α concentration versus time profiles in plasma and lymph following s.c. administration from our experimental (A, C, and D) and literature reported studies in rats (B) (Kojima et al., 1988). Solid circles are observed plasma concentrations and open circles are observed lymph concentrations. Solid and dashed lines depict model-fitted concentration profiles in plasma and lymph, respectively, with the parameters listed in Table 4.