TABLE 3.

Summary of model parameter estimates for rhTNF-α plasma PK

Parameter	Definition	Estimate	CV
			%
fd1	Fraction of (QCO–Qk) for V1	0.6663	380
fd2	Fraction of (QCO–Qk) for V2	0.007463	18.5
fdk	Fraction of Qk for Vk	0.8	Fixed
Kp	Partition coefficient	0.5172	11.9
V1 (ml)	ECF volume for tissue compartment 1	13.10	19.5
Vmax (ng/h)	Michaelis Menten capacity constant	3152	11.3
Km (ng/ml)	Michaelis Menten affinity constant	31.72	19.3
GSC	Glomerular sieving coefficient	0.1031	14.9

ECF, extracellular fluid.