Table 3. The association of miRNA polymorphisms and oral cancer risk stratified by sex.
| SNP | Oral cancer cases(%) | Controls (%) | OR (95%CI)* | P value | |
|---|---|---|---|---|---|
| Male | miR-196a2 rs11614913 | ||||
| TT(Ref.) | 81(30.0) | 82(31.1) | - | ||
| TC | 134(49.6) | 118(44.7) | 1.086(0.727–1.621) | 0.688 | |
| CC | 55(20.4) | 64(24.2) | 0.823(0.509–1.331) | 0.428 | |
| TC+CC vs TT | 189(70.0) | 182(68.9) | 0.993(0.683–1.444) | 0.971 | |
| CC vs TT+TC | 215(79.6) | 200(75.8) | 0.783(0.518–1.185) | 0.247 | |
| T allele(Ref.) | 296(54.8) | 282(53.4) | - | ||
| C allele | 244(45.2) | 246(46.6) | 0.945(0.743–1.202) | 0.645 | |
| miR-146a rs2910164 | |||||
| CC(Ref.) | 144(53.3) | 165(62.5) | - | ||
| CG | 105(38.9) | 83(31.4) | 1.504(1.038–2.180) | 0.031 | |
| GG | 21(7.8) | 16(6.1) | 1.504(0.834–3.386) | 0.147 | |
| CG+GG vs CC | 126(46.7) | 99(37.5) | 1.532(1.078–2.178) | 0.017 | |
| GG vs CC+CG | 249(92.2) | 248(93.9) | 1.439(0.725–2.857) | 0.298 | |
| C allele(Ref.) | 393(72.8) | 413(78.2) | - | ||
| G allele | 147(27.2) | 115(21.8) | 1.343(1.015–1.778) | 0.039 | |
| miR-499 rs3746444 | |||||
| TT(Ref.) | 153(56.7) | 174(65.9) | - | ||
| TC | 92(34.1) | 80(30.3) | 1.370(0.940–1.997) | 0.101 | |
| CC | 25(9.3) | 10(3.8) | 2.989(1.375–6.497) | 0.006 | |
| TC+CC vs TT | 117(43.3) | 90(34.1) | 1.550(1.085–2.214) | 0.016 | |
| CC vs TT+TC | 245(90.7) | 254(96.2) | 2.682(1.248–5.764) | 0.011 | |
| T allele(Ref.) | 398(73.7) | 428(81.1) | - | ||
| C allele | 142(26.3) | 100(18.9) | 1.527(1.143–2.041) | 0.004 | |
| Female | miR-196a2 rs11614913 | ||||
| TT(Ref.) | 19(27.1) | 15(19.7) | - | ||
| TC | 35(50.0) | 37(48.7) | 0.639(0.266–1.534) | 0.316 | |
| CC | 16(22.9) | 24(31.6) | 0.451(0.168–1.212) | 0.114 | |
| TC+CC vs TT | 51(72.9) | 61(80.3) | 0.564(0.247–1.288) | 0.174 | |
| CC vs TT+TC | 54(77.1) | 52(68.4) | 0.611(0.278–1.341) | 0.219 | |
| T allele(Ref.) | 73(52.1) | 67(44.1) | - | ||
| C allele | 67(47.9) | 85(55.9) | 0.723(0.456–1.147) | 0.168 | |
| miR-146a rs2910164 | |||||
| CC(Ref.) | 45(64.3) | 42(55.3) | - | ||
| CG | 19(27.1) | 31(40.8) | 0.552(0.260–1.174) | 0.123 | |
| GG | 6(8.6) | 3(3.9) | 1.895(0.420–8.544) | 0.405 | |
| CG+GG vs CC | 25(35.7) | 34(44.7) | 0.673(0.332–1.363) | 0.271 | |
| GG vs CC+CG | 64(91.4) | 73(96.1) | 2.339(0.532–10.286) | 0.261 | |
| C allele(Ref.) | 109(77.9) | 115(75.7) | - | ||
| G allele | 31(22.1) | 37(24.3) | 0.884(0.513–1.524) | 0.657 | |
| miR-499 rs3746444 | |||||
| TT(Ref.) | 38(54.3) | 43(56.6) | - | ||
| TC | 26(37.1) | 31(40.8) | 1.001(0.488–2.053) | 0.999 | |
| CC | 6(8.6) | 2(2.6) | 3.455(0.593–20.128) | 0.168 | |
| TC+CC vs TT | 32(45.7) | 33(43.4) | 1.145(0.573–2.288) | 0.702 | |
| CC vs TT+TC | 64(91.4) | 74(97.4) | 3.454(0.608–19.620) | 0.162 | |
| T allele(Ref.) | 102(72.9) | 117(77.0) | - | ||
| C allele | 38(27.1) | 35(23.0) | 1.245(0.733–2.117) | 0.417 |
Abbreviation: SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
*ORs were calculated by unconditional logistic regression and adjusted for age and smoking.