Table 4. The joint effects of miRNA polymorphisms and smoking on the risk of oral cancer.
Smoking | SNP | Cancer cases(%) | Controls (%) | OR (95%CI)* | P value |
---|---|---|---|---|---|
miR-196a2 rs11614913 | |||||
Never | CC(Ref.) | 47(13.8) | 48(14.1) | - | |
Never | CT+TT | 68(20.0) | 127(37.4) | 0.556(0.337–0.917) | 0.021 |
Smoking | CC | 53(15.6) | 49(14.4) | 1.113(0.636–1.948) | 0.708 |
Smoking | CT+TT | 172(50.6) | 116(34.1) | 1.531(0.960–2.444) | 0.074 |
miR-146a rs2910164 | |||||
Never | GG(Ref.) | 54(15.9) | 108(31.8) | - | |
Never | GC+CC | 61(17.9) | 67(19.7) | 1.811(1.124–2.918) | 0.015 |
Smoking | GG | 135(39.7) | 99(29.1) | 2.719(1.791–4.128) | <0.001 |
Smoking | GC+CC | 90(26.5) | 65(19.4) | 2.713(1.719–4.282) | <0.001 |
miR-499 rs3746444 | |||||
Never | TT(Ref.) | 53(15.6) | 115(33.8) | - | |
Never | TC+CC | 62(18.2) | 60(17.6) | 2.247(1.388–3.639) | 0.001 |
Smoking | TT | 138(40.6) | 102(30.0) | 2.925(1.933–4.428) | <0.001 |
Smoking | TC+CC | 87(25.6) | 63(18.5) | 3.013(1.901–4.777) | <0.001 |
Abbreviation: SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.
*ORs were calculated by unconditional logistic regression and adjusted for age and sex.