Table 4. The joint effects of miRNA polymorphisms and smoking on the risk of oral cancer.

Smoking	SNP	Cancer cases(%)	Controls (%)	OR (95%CI)*	P value
	miR-196a2 rs11614913
Never	CC(Ref.)	47(13.8)	48(14.1)	-
Never	CT+TT	68(20.0)	127(37.4)	0.556(0.337–0.917)	0.021
Smoking	CC	53(15.6)	49(14.4)	1.113(0.636–1.948)	0.708
Smoking	CT+TT	172(50.6)	116(34.1)	1.531(0.960–2.444)	0.074
	miR-146a rs2910164
Never	GG(Ref.)	54(15.9)	108(31.8)	-
Never	GC+CC	61(17.9)	67(19.7)	1.811(1.124–2.918)	0.015
Smoking	GG	135(39.7)	99(29.1)	2.719(1.791–4.128)	<0.001
Smoking	GC+CC	90(26.5)	65(19.4)	2.713(1.719–4.282)	<0.001
	miR-499 rs3746444
Never	TT(Ref.)	53(15.6)	115(33.8)	-
Never	TC+CC	62(18.2)	60(17.6)	2.247(1.388–3.639)	0.001
Smoking	TT	138(40.6)	102(30.0)	2.925(1.933–4.428)	<0.001
Smoking	TC+CC	87(25.6)	63(18.5)	3.013(1.901–4.777)	<0.001

Abbreviation: SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.

*ORs were calculated by unconditional logistic regression and adjusted for age and sex.