Table 3.
Biodistribution (SUV) of 63Zn-Zinc Citrate in Healthy Elderly Participants and Patients With AD.a
| Tissue | PET Scan at 45-70 Minutes | PET Scan at 95-120 Minutes | ||
|---|---|---|---|---|
| Healthy | Patients With AD | Healthy | Patients With AD | |
| AD-global | 0.39 ± 0.05 | 0.37 ± 0.07 | 0.35 ± 0.05 | 0.35 ± 0.06 |
| Parietal | 0.36 ± 0.05 | 0.34 ± 0.06 | 0.33 ± 0.04 | 0.33 ± 0.06 |
| Cingulate, precuneus | 0.41 ± 0.05 | 0.38 ± 0.06 | 0.37 ± 0.05 | 0.37 ± 0.05 |
| Prefrontal cortex | 0.37 ± 0.05 | 0.36 ± 0.07 | 0.33 ± 0.05 | 0.33 ± 0.06 |
| Orbitofrontal | 0.39 ± 0.06 | 0.36 ± 0.06 | 0.32 ± 0.06 | 0.33 ± 0.08 |
| Lateral temporal | 0.39 ± 0.05 | 0.37 ± 0.08 | 0.35 ± 0.05 | 0.34 ± 0.07 |
| Primary visual cortex | 0.50 ± 0.06 | 0.46 ± 0.09 | 0.44 ± 0.06 | 0.44 ± 0.08 |
| Cerebellum | 0.46 ± 0.05 | 0.46 ± 0.09 | 0.41 ± 0.06 | 0.41 ± 0.08 |
| Anterior cingulate | 0.34 ± 0.05 | 0.31 ± 0.06 | 0.30 ± 0.05 | 0.28 ± 0.05 |
| Occipital cortex | 0.44 ± 0.05 | 0.41 ± 0.08 | 0.40 ± 0.05 | 0.40 ± 0.07 |
| Medial temporal | 0.39 ± 0.06 | 0.36 ± 0.06 | 0.35 ± 0.07 | 0.33 ± 0.04 |
| Pons | 0.45 ± 0.08 | 0.42 ± 0.09 | 0.36 ± 0.05 | 0.38 ± 0.09 |
| Pituitary | 3.00 ± 0.48 | 2.78 ± 0.65 | 2.61 ± 0.42 | 2.65 ± 0.261 |
| Parotid gland | 2.56 ± 1.10 | 2.43 ± 0.42 | 2.47 ± 0.92 | 2.64 ± 0.55 |
| Submandibular gland | 3.17 ± 0.67 | 3.14 ± 0.51 | 3.32 ± 0.62 | 3.12 ± 0.68 |
| Thyroid | 3.94 ± 1.01 | 4.15 ± 1.93 | 4.17 ± 1.05 | 4.26 ± 1.70 |
| Lung | 0.27 ± 0.12 | 0.30 ± 0.15 | 0.30 ± 0.09 | 0.31 ± 0.11 |
| Heart | 0.81 ± 0.22 | 1.10 ± 0.17 | 0.76 ± 0.21 | 1.17 ± 0.14 |
| Breast (females) | 0.04 ± 0.04 | 0.09 ± 0.12 | 0.05 ± 0.06 | 0.10 ± 0.11 |
| Liver | 33.2 ± 3.1 | 30.6 ± 7.5 | 34.3 ± 5.0 | 31.3 ± 7.9 |
| Spleen | 4.46 ± 0.60 | 5.00 ± 0.70 | 4.12 ± 0.71 | 4.85 ± 0.48 |
| Pancreas | 12.1 ± 4.0 | 13.0 ± 3.8 | 13.5 ± 3.4 | 12.4 ± 2.9 |
| Stomach | 4.34 ± 1.08 | 3.96 ± 0.87 | 4.68 ± 0.88 | 5.07 ± 1.07 |
| Ileum | 5.66 ± 1.13 | 4.68 ± 0.41 | 5.47 ± 1.56 | 4.77 ± 1.89 |
| Kidney | 9.94 ± 1.02 | 10.72 ± 1.69 | 10.09 ± 1.30 | 10.80 ± 1.79 |
| Prostate (males) | 3.15 ± 0.04 | 3.14 ± 2.07 | 3.90 ± 0.52 | 3.67 ± 3.02 |
| Testicles (males) | 0.57 ± 0.36 | 0.70 ± 0.27 | 0.42 ± 0.08 | 0.62 ± 0.02 |
| Bone | 0.24 ± 0.10 | 0.21 ± 0.11 | 0.24 ± 0.24 | 0.25 ± 0.12 |
| Bone marrow | 1.41 ± 0.20 | 1.40 ± 0.31 | 1.42 ± 0.47 | 1.50 ± 0.54 |
| Skeletal muscle | 0.17 ± 0.03 | 0.16 ± 0.06 | 0.16 ± 0.02 | 0.18 ± 0.04 |
Abbreviations: AD, Alzheimer disease; PET, positron emission tomography; SUV, standardized uptake value.
aNo statistically significant differences were found on comparing AD and healthy groups at these time points.