Figure 3.

Biodistribution of ¹¹¹In-DTPA-ITGA6B4 in tumor-bearing mice. Radioactivity of samples was measured at 1.5 hours (white bar), 24 hours (pale gray bar), 48 hours (gray bar), 72 hours (dark gray bar), and 96 hours (black bar) after receiving intravenous injection of ¹¹¹In-DTPA-ITGA6B4. Injected dose of ¹¹¹In-DTPA-ITGA6B4 (26 kBq) was adjusted to 5 μg per mouse by the addition of unlabeled antibody. Data are presented as mean ± SD (n = 5 for each group; *P < .02 vs radioactivity of A4 tumor at each time point). DTPA indicates N-[(R)-2-amino-3-(p-isothiocyanato-phenyl)propyl]-trans-(S, S)-cyclohexane-1,2-diamine-N, N, N′, N″, N″-pentaacetic acid; SD, standard deviation