FIGURE 1:

Podocyte IRE1α-deletion male mice develop albuminuria with aging. Male (A) and female (B) F3 littermates were monitored for albuminuria monthly. Podocyte IRE1α deletion in male mice (IRE1α^{flox/flox;Cre}; M Cre) caused persistent and worsening albuminuria beginning at 5 mo of age as compared with control (IRE1α^flox/flox;+; M +). Male mice: p = 4.72 × 10^–4 (M Cre vs. M +; genotype); p = 2.20 × 10^–6 (age); p = 0.033 (genotype × age interaction). There were no significant differences in albuminuria between female Cre (F Cre) and control (F +) mice. Number of urine samples (N) is indicated under each column.