Table 4.
KIAA0319 Francks haplotype with JA04 and 13 bp repeat
Haplotype—marker alleles
|
Haplotype frequency | Transmission
|
||||||||
---|---|---|---|---|---|---|---|---|---|---|
rs4504469 | rs2038137 | JA04 | rs71815143 | rs2143340 | Obs | Exp. | Var (O–E) | χ2 | p-value (1 d.f.) | |
2 (A) | 2 (A) | 14 (25 GT) | 1 (ins) | 1 (T) | 0.060 | 22.903 | 16.952 | 5.2399 | 6.7599 | 0.0093 |
2 (A) | 2 (A) | 16 (27 GT) | 1 (ins) | 1 (T) | 0.053 | 13 | 14.5 | 8.801 | 0.2556 | 0.6132 |
1 (G) | 1 (C) | 1 (11 GT) | 2 (del) | 1 (T) | 0.147 | 39.861 | 46.366 | 21.501 | 1.9676 | 0.1607 |
1 (G) | 1 (C) | 2 (12 GT) | 2 (del) | 1 (T) | 0.122 | 30.038 | 33.06 | 12.026 | 0.7598 | 0.3834 |
1 (G) | 1 (C) | 8 (18 GT) | 2 (del) | 2 (C) | 0.095 | 28 | 30 | 13.575 | 0.2946 | 0.5873 |
Global χ2 (51 d.f.) = 112.45; p = 0.000002
χ2 on haplotypes with freq >10% (2 d.f.) = 3.1161; p = 0.2105
χ2 on haplotypes with freq >5% (5 d.f.) = 9.7402; p = 0.0829