Table 2.

Clinical Presentation, Treatment, p16/HPV Status, and Outcome for Patients with Available Tumor Tissue

Site	TNM classification	Grade	Therapy	p16 status	p16 intensity	% of p16+ tumor cells	HPV status	Local failure	Distant failure	Follow-up
Maxillary sinus	T4N0M0	Cribriform	S+RT	−	2	30	−	Yes	Yes	DOD
Maxillary sinus	T4N0M0	Cribriform	S+IORT+RT	+	3	70	−	Yes	Yes	M
Maxillary sinus	T4N0M0	Cribriform	S	−	2	60	−	No	Yes	DOD
Maxillary sinus	T4N0M0	Cribriform	S+RT	−	3	20	−	Yes	No	DOD
Maxillary sinus	T4N0M0	Solid	S+RT	−	3	50	−	No	No	NED
Maxillary sinus	T4N0M0	Cribriform	S+RT	−	2	40	−	Yes	Yes	DOD
Maxillary sinus	T3N0M0	Cribriform	S	−	2	10	−	Yes	Yes	DOD
Maxillary sinus	T3N0M0	Solid	S+IORT	−	3	20	−	No	Yes	DOD
Maxillary sinus	T3N0M0	Cribriform	S+RT	−	2	30	−	Yes	Yes	M
Nasal cavity	T4N0M0	Cribriform	S+RT	−	2	50	−	No	No	NED
Nasal cavity	T4N0M0	Solid	S+RT	−	2	10	−	Yes	Yes	DOD
Nasal cavity	T3N0M0	Cribriform	S+CRT	−	3	50	−	No	No	NED
Nasal cavity	T3N0M0	Cribriform	S+RT	−	2	10	−	No	No	NED
Nasal cavity	T2N0M0	Solid	S	+	3	100	+	Yes	Yes	DOD
Nasal cavity	T1N0M0	Cribriform	S	−	3	60	−	No	No	NED
Sphenoid sinus	T4N0M0	Cribriform	S+RT	−	3	40	−	No	Yes	DOD
Ethmoid sinus	T3N0M0	Tubular	S+RT	−	3	50	−	Yes	No	DOD

Abbreviations: CRT=concurrent chemoradiation; DOD=dead of disease; IORT=intraoperative radiation therapy; M=metastatic disease; NED=no evidence of disease; RT=external beam radiation therapy; S=surgery