Table 2.
Performance of MTBDRplus 2.0 for detecting tuberculosis in clinical sputum samples.
| Site | Culture | GeneXpert | |||||
|---|---|---|---|---|---|---|---|
| Sensitivity | Specificity | Agreement | |||||
| All culture-positive | Smear-positive and culture-positive | Smear-negative and culture-positive | No tuberculosis | Smear-positive | Smear-negative | Total | |
| Guangzhou (%) | 434/455(95.4) | 315/316(99.7) | 119/139(85.6) | 684/728(94.0) | 311/317(98.1) | 857/875(97.9) | 1168/1192(98.0) |
| 95% CI | 93.0–97.1 | 98.3–100.0 | 78.66–90.98 | 92.0–95.6 | 95.9–99.3 | 96.8–98.8 | 97.0–98.7 |
| Shanghai (%) | 380/410(92.7) | 230/239(96.2) | 150/171(87.7) | 728/756(96.3) | 252/262(96.2) | 919/958(95.9) | 1171/1220(96.0) |
| 95% CI | 89.7–95.0 | 93.0–98.3 | 83.0–93.1 | 94.7–97.5 | 93.1–98.2 | 94.5–97.1 | 94.7–97.0 |
| Anhui (%) | 462/505(91.5) | 221/229(96.5) | 241/276(87.3) | 637/684(93.1) | 224/228(99.6) | 928/958(96.9) | 1152/1186(97.1) |
| 95% CI | 88.7–93.8 | 93.2–98.5 | 82.8–91.0 | 91.0–94.9 | 95.6–99.5 | 95.6–97.9 | 96.0–98.0 |
| Xi’an (%) | 447/488(91.6) | 229/234(97.9) | 218/254(85.8) | 706/747(94.5) | 228/232(98.3) | 978/1003(97.5) | 1206/1235(97.7) |
| 95% CI | 88.8–93.9 | 95.1–99.3 | 80.9–89.9 | 92.6–96.0 | 95.6–99.5 | 96.3–98.4 | 96.6–98.4 |
| Total (%) | 1723/1858(92.7) | 995/1018(97.7) | 728/840(86.7) | 2755/2915(94.5) | 1015/1039(97.7) | 3682/3794(97.0) | 4697/4833(97.2) |
| 95% CI | 91.5–93.9 | 96.6–98.6 | 84.2–88.9 | 93.6–95.3 | 96.6–98.5 | 96.5–97.6 | 96.7–97.6 |
CI: confidence interval.