Table 4.
Performance of MTBDRplus assay for detecting isoniazid resistance.
| Site | MTBDRplus | Culture | Total | Sensitivity (%, 95% CI) | Specificity (%, 95% CI) | Positive predictive value (%, 95% CI) | Negative predictive value (%, 95% CI) | |
|---|---|---|---|---|---|---|---|---|
| R | S | |||||||
| Guangzhou | R | 72 | 9 | 81 | 78.3 (68.4–86.2) | 97.1 (94.5–98.7) | 88.9 (80.0–94.8) | 93.7 (90.5–96.1) |
| S | 20 | 299 | 319 | |||||
| Total | 92 | 308 | 400 | |||||
| Shanghai | R | 92 | 7 | 99 | 81.4 (73.0–88.1) | 97.1 (94.2–98.8) | 92.9 (86.0–97.1) | 91.9 (87.9–94.9) |
| S | 21 | 238 | 259 | |||||
| Total | 113 | 245 | 358 | |||||
| Anhui | R | 72 | 14 | 86 | 94.7 (87.1–98.6) | 96.2 (93.7–97.9) | 83.7 (74.2–90.8) | 98.9 (97.2–99.7) |
| S | 4 | 356 | 360 | |||||
| Total | 76 | 370 | 446 | |||||
| Xi’an | R | 96 | 7 | 103 | 74.4 (66.0–81.7) | 97.7 (95.3–99.1) | 93.2 (86.5–97.2) | 89.9 (86.1–93.0) |
| S | 33 | 294 | 327 | |||||
| Total | 129 | 301 | 430 | |||||
| Total | R | 332 | 37 | 369 | 81.0 (76.8–84.7) | 97.0 (95.9–97.9) | 90.0 (86.4–92.8) | 93.8 (92.4–95.1) |
| S | 78 | 1187 | 1265 | |||||
| Total | 410 | 1224 | 1634 | |||||