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. 2017 Jun 13;7:3420. doi: 10.1038/s41598-017-03744-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SerpinB3 up-regulates expression of genes involved in liver fibrogenesis in immortalized human HSC (LX2 cells). (a) Analysis by quantitative real-time PCR (Q-PCR) of transcript levels of pro-fibrogenic genes, of CCL2 as well as of (b) VEGF-A or angiopoietin 1 (Ang-1) in human LX2 cells exposed for the indicated time points to 100 ng/ml human recombinant SerpinB3 (SB3). Data are expressed as means ± SEM of three independent experiments (*p < 0.05 or **p < 0.01 vs control values). (c,d) WB Analysis of VEGF-A protein in total extracts (left panel) and immuno-precipitated VEGF-A protein levels released in the extracellular medium collected at the indicated time points. The cropped gels shows in this Fig. have been run under the same experimental conditions.