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. 2017 Jun 13;7:3385. doi: 10.1038/s41598-017-03457-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The muPA:Nb7 complex crystal structure. (a) Overall structure of the serine protease domain of muPA (teal) in complex with Nb7 (red). (b) Superposition of the structure around the 140s loop in muPA:Nb7 with the 2F _o–F _c and F _o–F _c electron density maps at contour level σ = 1 (grey) and σ = ±3 (+green, −red) respectively. Black dashed line indicates a potential backbone trace of the 140s loop. (c) Structural comparison of the 37s and 70s loops in muPA between the muPA:Nb22 (orange) and muPA:Nb7 (teal) structures. (d) Superposition of the 70s/140s polar interaction network in muPA:Nb22 (orange) and muPA:Nb7 (teal) represented by sticks. (e) Structural comparison of the catalytic residues in muPA between the muPA:Nb22 structure (orange) and the muPA:Nb7 structure (teal).