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. 2017 Jun 13;7:3331. doi: 10.1038/s41598-017-03187-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The mRNA expression levels of OPG and RANKL on the femur. The mRNA expression levels were measured by qRT-PCR for OPG (A), RANKL (B). OPG/RANKL ratio (C). Data were the means ± SD (n = 6 for each group). ^# P < 0.05 and ^## P < 0.01, vs. the SHAM group. *P < 0.05 and **P < 0.01, vs. the DEX group. The mRNA expression levels of the LRP5/beta-catenin pathway on femur. The mRNA expression levels were measured by qRT-PCR for LRP5 (D), beta-catenin (E). Data were the means ± SD (n = 6 for each group). ^# P < 0.05 and ^## P < 0.01, vs. the SHAM group. *P < 0.05 and **P < 0.01, vs. the DEX group.