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. 2017 Jun 13;7:3396. doi: 10.1038/s41598-017-03645-5

Table 2.

Antagonism of IGFBP-3 does not change undisturbed maternal behaviour and elevated plus-maze test performance of rat dams. The ratio of 5 examined elements of maternal behaviours is shown in the table. In the elevated plus maze test, unchanged total number of entries suggest unaltered motility of the animals while the lack of significantly changed open arm entry frequency suggest unaltered anxiety-like behaviour.

ACSF IGF DMSO NBI-31772
total number of entries 10.57 ± 2.01 11.4 ± 1.65 12 ± 1.78 11 ± 1.58
open arm entries (%) 46.33 ± 3.24 36.36 ± 6 46.66 ± 4.51 45.22 ± 5.07
high kyphosis (%) 26 ± 2.34 21.43 ± 2.22 23.8 ± 1.98 23 ± 2.68
licking/grooming (%) 7.03 ± 0.54 5.13 ± 0.73 6 ± 0.84 7.96 ± 1.43
prone nursing (%) 21.14 ± 8.15 21.71 ± 7.91 24.62 ± 15.46 20.22 ± 5.24
supine nursing (%) 5.23 ± 4.17 7.17 ± 5.4 7.76 ± 7.91 6.8 ± 4.56
out of the nest (%) 42 ± 3.08 45.71 ± 3.1 39 ± 5.08 44.9 ± 4.72