Table 3.
Antibacterial and antifungal activity of Chrysophsin-1 and its variants.
| Minimum inhibitory concentration (MIC) in µM | |||||||
|---|---|---|---|---|---|---|---|
| Gram-Negative Bacteria | Chr-1 | G8P Chr-1 | G13P Chr-1 | G18P Chr-1 | G13,18P Chr-1 | Norfloxacin | Gentamicin |
| Escherichia coli (ATCC 9637) | 3.4 | 3.3 | 3 | 3 | 6.8 | 0.15 | 5 |
| Escherichia coli (ATCC 25922) | 3 | 4.1 | 5 | 3 | 4 | 0.3 | 2.5 |
| Pseudomonas aeruginosa (ATCC BAA-427) | 6.8 | 6.8 | 6.8 | 6.8 | 13.6 | 1.22 | 1.35 |
| Klebsiella pneumoniae (ATCC 27736) | 3 | 3.3 | 6.8 | 13.6 | 27.2 | 0.15 | 1.35 |
| Gram-Positive Bacteria | |||||||
| Bacillus subtilis (ATCC 6633) | 6 | 3 | 3 | 3 | 3 | 1.2 | 1.2 |
| Staphylococcus aureus (ATCC 25923) | 3 | 3 | 3 | 3 | 3 | 1.22 | 0.67 |
| Staphylococcus aureus (ATCC 700698 MRSA) | 3 | 1.6 | 3 | 3 | 3 | >156 | >86.8 |
| Staphylococcus aureus (ATCC 700699 MRSA) | 1.6 | 1.6 | 1.6 | 3 | 3 | >156 | >86.8 |
| Staphylococcus aureus (BAA-44)MDR | 1.6 | 1.6 | 1.6 | 3 | 3 | 39.14 | >86.8 |
| Staphylococcus aureus (ATCC 29213) | 1.6 | 1.6 | 1.6 | 6.8 | 3 | 2.44 | 1.35 |
| Staphylococcus aureus (ATCC 33592)Methicillin resistantGenatmicin resistant | 1.6 | 0.8 | 1.6 | 1.6 | 1.6 | 1.22 | >86.8 |
| Fungi | Fluconazole | ||||||
| Candida albicans (ATCC 10231) | 6.8 | 3 | 13.6 | 13.6 | >30 | 3.26 | |
| Cryptococcus neoformans | 3 | 6.8 | 13.6 | 13.6 | >30 | 6.53 | |
| Candida parapsilosis (ATCC 22019) | 3 | 6.8 | 6.8 | 13.6 | >30 | 6.53 | |
| Sporothrix schenckii (Patient isolates) | 13.6 | 13.6 | 27.2 | 27.2 | >30 | 6.53 | |