Table 3.
Subgroup analyses of crude relative risk for myocardial infarction and adjusted relative risk for myocardial infarction.
| Outcomes | Group | RR and 95%CI | P value | Heterogeneity (%) | P value for heterogeneity | P value between subgroups |
|---|---|---|---|---|---|---|
| Crude relative risk for myocardial infarction | Publication year | |||||
| 2010 or after | 1.43 (1.09–1.87) | 0.011 | 93.1 | <0.001 | 0.006 | |
| Before 2010 | 0.77 (0.37–1.60) | 0.482 | 90.3 | <0.001 | ||
| Study design | ||||||
| Prospective | 1.05 (0.75–1.47) | 0.789 | 92.5 | <0.001 | <0.001 | |
| Retrospective | 1.53 (1.05–2.23) | 0.027 | 90.3 | <0.001 | ||
| Region | ||||||
| North America | 0.92 (0.60–1.39) | 0.68 | 93.7 | <0.001 | <0.001 | |
| Europe | 1.60 (0.97–2.64) | 0.065 | — | — | ||
| Asia | 1.72 (1.13–2.61) | 0.011 | 92.9 | <0.001 | ||
| International | 1.23 (0.99–1.53) | 0.061 | — | — | ||
| Sample size | ||||||
| 10000 or greater | 1.42 (1.02–1.97) | 0.036 | 94 | <0.001 | 0.016 | |
| <10000 | 0.91 (0.53–1.57) | 0.743 | 87.9 | <0.001 | ||
| Mean age | ||||||
| 60 or older | 1.33 (1.16–1.51) | <0.001 | 63.9 | 0.017 | 0.005 | |
| <60 | 1.07 (0.45–2.59) | 0.872 | 96.8 | <0.001 | ||
| Women proportion | ||||||
| ≥50% | 1.20 (0.88–1.63) | 0.246 | 93.6 | <0.001 | 0.051 | |
| <50% | 1.21 (0.77–1.91) | 0.41 | 92.2 | <0.001 | ||
| Previous myocardial infarction | ||||||
| ≥20% | 0.92 (0.52–1.63) | 0.774 | 87.4 | <0.001 | 0.025 | |
| <20% | 1.24 (0.86–1.77) | 0.248 | 93.7 | <0.001 | ||
| Adjustment degree | ||||||
| +++ | 1.19 (0.83–1.70) | 0.347 | 95.5 | <0.001 | 0.631 | |
| None | 1.28 (1.12–1.47) | <0.001 | 0 | 0.455 | ||
| Follow-up duration | ||||||
| ≥5 years | 1.15 (0.70–1.90) | 0.586 | 96.4 | <0.001 | 0.148 | |
| <5 years | 1.31 (1.19–1.43) | <0.001 | 0 | 0.599 | ||
| Adjusted relative risk for myocardial infarction | Publication year | |||||
| 2010 or after | 1.45 (1.07–1.99) | 0.018 | 91.3 | <0.001 | 0.241 | |
| Before 2010 | 1.02 (0.66–1.58) | 0.93 | — | — | ||
| Study design | ||||||
| Prospective | 1.48 (1.25–1.74) | <0.001 | 35.4 | 0.2 | 0.013 | |
| Retrospective | 1.34 (0.66–2.72) | 0.414 | 95.9 | <0.001 | ||
| Region | ||||||
| North America | 1.48 (1.25–1.74) | <0.001 | 35.4 | 0.2 | 0.002 | |
| Europe | 0.77 (0.53–1.11) | 0.166 | — | — | ||
| Asia | 1.75 (0.65–4.73) | 0.272 | 97.6 | <0.001 | ||
| Sample size | ||||||
| 10000 or greater | 1.42 (0.84–2.41) | 0.188 | 94.3 | <0.001 | 0.106 | |
| <10000 | 1.41 (1.15–1.73) | 0.001 | 46.6 | 0.154 | ||
| Mean age | ||||||
| 60 or older | 1.20 (0.92–1.56) | 0.187 | 81.5 | 0.001 | <0.001 | |
| <60 | 1.73 (1.02–2.93) | 0.04 | 89.3 | <0.001 | ||
| Women proportion | ||||||
| ≥50% | 1.40 (1.10–1.78) | 0.007 | 83 | 0.001 | 0.036 | |
| <50% | 1.33 (0.55–3.24) | 0.528 | 94.6 | <0.001 | ||
| Previous myocardial infarction | ||||||
| ≥20% | 1.02 (0.66–1.58) | 0.93 | — | — | <0.001 | |
| <20% | 1.24 (0.91–1.70) | 0.18 | 86.6 | <0.001 | ||
| Adjustment degree | ||||||
| +++ | 1.39 (1.05–1.85) | 0.022 | 89.8 | <0.001 | — | |
| ++ | — | — | — | — | ||
| Follow-up duration | ||||||
| ≥5 years | 1.47 (1.07–2.02) | 0.018 | 87.1 | <0.001 | <0.001 | |
| <5 years | 1.06 (0.93–1.20) | 0.366 | — | — | ||