Table 2.

Metabolic characteristics of db/m and db/db mice treated with vehicle (drinking water) or ONO-AE3-208 (10 mg/kg/day) or db/db mice treated with captopril (20 mg/kg/day) for eight weeks.

	n	Body weight (g)	Mean kidney weight (g)	Mean kidney weight: body weight (%)	Systolic blood pressure (mmHg)	Blood glucose (mmol/L)
db/m	12	30.7 ± 0.6	0.199 ± 0.003	0.65 ± 0.01	90 ± 5	7.8 ± 0.3
db/m + ONO-AE3-208	12	29.2 ± 0.6	0.204 ± 0.006	0.70 ± 0.03	97 ± 3	8.0 ± 0.4
db/db	10	37.9 ± 1.1ab	0.237 ± 0.005af	0.63 ± 0.03	104 ± 6d	29.7 ± 1.0ab
db/db + ONO-AE3-208	7	36.6 ± 1.9bc	0.212 ± 0.012g	0.57 ± 0.47	98 ± 5	28.8 ± 1.0ab
db/db + captopril	8	34.5 ± 2.0de	0.233 ± 0.008fh	0.64 ± 0.04	80 ± 6ijk	28.9 ± 1.3ab

^ap < 0.0001 vs. db/m, ^bp < 0.0001 vs. db/m + ONO-AE3-208, ^cp < 0.01 vs. db/m, ^dp < 0.05 vs. db/m, ^ep < 0.01 vs. db/m + ONO-AE3-208, ^fp < 0.001 vs. db/m + ONO-AE3-208, ^gp < 0.05 vs. db/db, ^hp < 0.001 vs. db/m, ⁱp < 0.05 vs. db/m + ONO-AE3-208, ^jp < 0.01 vs. db/db, ^kp < 0.05 vs. db/db + ONO-AE3-208.