Table 3.

Metabolic characteristics of sham-operated and subtotally nephrectomized (SNx) rats treated with vehicle (drinking water) or ONO-AE3-208 for seven weeks.

	n	Body weight (g)	Left kidney weight (g)	Left kidney weight:body weight (%)	Systolic blood pressure (mmHg)	GFR (ml/min/kg)
Sham	12	617 ± 15	1.678 ± 0.037	0.28 ± 0.01	125 ± 2	7.8 ± 0.5
Sham + ONO-AE3-208 (10 mg/kg/day)	12	593 ± 17	1.732 ± 0.058	0.29 ± 0.01	132 ± 3	8.2 ± 0.7
SNx	18	516 ± 15ab	2.319 ± 0.068af	0.45 ± 0.01af	196 ± 11af	2.4 ± 0.4af
SNx + ONO-AE3-208 (1 mg/kg/day)	8	510 ± 20bc	2.084 ± 0.129bdg	0.41 ± 0.02ah	184 ± 9ah	3.1 ± 0.7af
SNx + ONO-AE3-208 (10 mg/kg/day)	8	525 ± 23de	2.052 ± 0.108bdg	0.36 ± 0.04dei	181 ± 5ah	3.2 ± 0.6af

^ap < 0.0001 vs. sham, ^bp < 0.01 vs. sham + ONO-AE3-208, ^cp < 0.001 vs. sham, ^dp < 0.01 vs. sham, ^ep < 0.05 vs. sham + ONO-AE3-208, ^fp < 0.0001 vs. sham + ONO-AE3-208, ^gp < 0.05 vs. SNx, ^hp < 0.001 vs. sham + ONO-AE3-208, ⁱp < 0.001 vs. SNx.