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. 2017 Jun 13;7:3418. doi: 10.1038/s41598-017-03511-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BGT induced apoptosis in A549 cells. (a) A549 cells treated with indicated concentration of BGT for 48 h, stained by DAPI and observed in fluorescence microscopy. The arrow heads indicates chromatin condensation with changes of nuclear morphology and DNA fragmentations. (b) DNA fragmentation of BGT treated A549 cells. M-1kb ladder DNA, C-Control and Lane 1–4 is different concentration of BGT (50–200 μg/mL) treated A549 cells. (c) Fluorescence microscopy images of Annexin-V/FITC and DAPI stained BGT treated and control cells. (d) Quantitative measurement of apoptotic cells after BGT treatment with the indicated concentration at 48 h. (e) Fluorescence microscopy images of AO/ETBR stained BGT treated A549 cells after 48 h. All the images were acquired in 200X magnification. *p < 0.01 denote the statistical significance between the control and treated groups.