Table 2.
Clinical parameters, characteristics of the dietary survey, and analytic parameters in patients with and without azithromycin
| Azithromycin (n=23) | No treatment (n=13) | Significance | |
|---|---|---|---|
| Age (m±sd) | 28.4±9.5 | 25.2±7.5 | NS |
| Sex n (%) | NS | ||
| Male | (11) 47.8% | (7) 53.8% | |
| Female | (12) 52.2% | (6) 46.2% | |
| F508del | 7.7% | 39.1% | 0.034 |
| Sweat test (mmol/L) (m±sd) | 114.4±12.2 | 104.5±13.6 | 0.026 |
| BMI (kg/m2) | 22.1±2.8 | 23.1±3.9 | NS |
| Fat-free mass index (kg/m2) | 17.2±2.3 | 17.6±2.1 | NS |
| Dynamometry (kg) | 26.9±12.2 | 29.0±13.3 | NS |
| Diabetes n (%) | NS | ||
| No | (16) 69.6% | (8) 61.5% | |
| Yes | (7) 30.4% | (5) 38.5% | |
| Exocrine pancreatic insufficiency | NS | ||
| No | (7) 30.4% | (5) 38.5% | |
| Yes | (16) 69.6% | (8) 61.5% | |
| Meconium ileus n (%) | 0.044 | ||
| No | (17) 73.9% | (13) 100% | |
| Yes | (6) 26.1% | (0) 0% | |
| Respiratory insufficiency with effort | NS | ||
| No | (1) 7.7% | (12) 92.3% | |
| Yes | (6) 26.1% | (28) 77.8% | |
| Colonizations | 100% | 76.9% | 0.016 |
| Exacerbations | 3.1±2.1 | 1.2±1.2 | 0.003 |
| Mild exacerbations | 1.2±1.1 | 2.4±1.6 | 0.016 |
| Severe exacerbations | 0.7±1.3 | 0.15±1.4 | 0.05 |
| Bhalla | 14.1±3.6 | 17.0±2.7 | 0.022 |
| FEV1 (%) | 47.1±21.3% | 77.1±20.9% | 0.000 |
| FVC (%) | 60.1±21.8% | 82.9±17.1% | 0.003 |
| Albumin (mg/dL) | 3.7±0.4 | 3.9±0.3 | NS |
| Prealbumin (mg/dL) | 20.2±5.5 | 21.9±5.9 | NS |
| Vitamin A (mcg/dL) | 29.5±8.8 | 31.2±10.3 | NS |
| Vitamin D (mcg/dL) | 21.8±9.7 | 30.9±14.0 | 0.035 |
| Vitamin E (mcg/dL) | 833.0±190.1 | 937.4±370.8 | NS |
| Vitamin E/Cholesterol (mg/g) | 7.1±1.1 | 7.0±2.3 | NS |
| Zinc (mcg/dL) | 84.3±12.3 | 88.5±16.62 | NS |
| OXIDATION | |||
| Total antioxidant capacity (mM) | 2.0±1.2 | 2.1±0.8 | NS |
| Catalase activity (nmol/min/mL) | 116.1±33.7 | 125.2±35 | NS |
| Superoxide dismutase (SOD) activity (UI/mL) | 6.8±2.0 | 8.1±1.9 | NS (0.06) |
| Glutathione peroxidase (GPx) activity (nmol/min/mL) | 90.3±8.3 | 85.6±6.4 | NS |
| TBARS (lipid peroxidation micromol/L) | 0.147±0.04 | 0.137±0.05 | NS |
| Isoprostanes (8-iso-PG2α) (pg/mL) | 112.8±32.9 | 109.6±38.6 | NS |
| INFLAMMATION | |||
| IL-6 (pg/mL) | 13.9±24 | 9.7±10 | NS |
| TNF-α (pg/mL) | 3.1±0.6 | 4.5±2 | 0.010 |
| RCP (mg/L) | 13.9±14 | 8.2±11.5 | NS |
BMI: Body Mass Index; FEV1: forced expiratory volume in one second; FVC: forced vital capacity; TBARS: thiobarbituric acid reactive substances; IL-6: interleukin-6; TNF-α: tumor necrosis factor alpha; RCP: reactive C protein