Table 3.
Differentially expressed proteins identified in synovial fluid.
| Description | Accession | Peptide count | Unique peptides | q-value | Mean FC (H/L) | Ref |
|---|---|---|---|---|---|---|
| Neuroblastoma suppressor of tumorigenicity 1 (NBL1) | P41271 | 2 | 2 | 1.26E-07 | 0.33 | 34 |
| Histidine protein methyltransferase 1 homolog (METTL18) | O95568 | 2 | 1 | 2.50E-06 | 3.29 | |
| Calreticulin (CALR) | P27797 | 2 | 2 | 1.37E-05 | 0.28 | |
| SWI/SNF complex subunit SMARCC1 (SMARCC1) | Q92922;Q9UL12 | 2 | 1 | 2.17E-05 | 0.31 | |
| Collagen alpha-1(VI) chain (COL6A1) | P12109 | 3 | 2 | 8.15E-05 | 0.47 | 33, 34 |
| Adenylyl cyclase-associated protein 1 (CAP1) | Q01518 | 2 | 1 | 1.41E-04 | 1.0E-06 | |
| Kinesin-like protein KIF26B (KIF26B) | Q2KJY2 | 3 | 1 | 1.08E-03 | 15.12 | |
| Tubulin alpha-1B chain (TUBA1B) | P68363;A6NHL2;P68366;Q13748;Q71U36 | 4 | 4 | 2.75E-03 | 2.27 | |
| Adiponectin (ADIPOQ) | Q15848 | 2 | 2 | 3.90E-03 | 0.19 | 34 |
| Integrin beta-like protein 1 (ITGBL1) | O95965 | 3 | 3 | 5.22E-03 | 0.39 | |
| Thrombospondin-3 (THBS3) | P49746 | 3 | 1 | 6.51E-03 | 5.85 | 34 |
| Coronin-1A (CORO1A) | P31146 | 8 | 8 | 6.69E-03 | 3.47 | |
| Golgin subfamily B member 1 (GOLGB1) | Q14789 | 3 | 2 | 7.33E-03 | 3.92 | |
| Collagen alpha-1(V) chain (COL5A1) | P20908 | 3 | 2 | 1.03E-02 | 4.78 | 34 |
| Neutrophil defensin 1 (DEFA1) | P59665 | 3 | 3 | 1.53E-02 | 3.03 | |
| Ganglioside GM2 activator (GM2A) | P17900 | 2 | 2 | 3.00E-02 | 3.28 | 34 |
| Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) | P98066 | 5 | 5 | 3.19E-02 | 0.43 | 34 |
| Common plasma proteins | ||||||
| Apolipoprotein A-II (APOA2) | P02652 | 8 | 7 | 3.82E-09 | 0.34 | 33, 35 |
| Alpha-1-antitrypsin (SERPINA1) | P01009 | 17 | 17 | 1.52E-07 | 0.33 | 34, 35 |
| Vitamin K-dependent protein Z (PROZ) | P22891 | 9 | 9 | 1.85E-06 | 0.32 | 34 |
| Plasma protease C1 inhibitor (SERPING1) | P05155 | 7 | 5 | 7.53E-06 | 0.41 | 34, 35 |
| Haemopexin (HPX) | P02790 | 3 | 3 | 3.87E-05 | 0.39 | 33, 35 |
| Apolipoprotein C-I (APOC1) | P02654 | 2 | 2 | 2.79E-04 | 0.18 | 33 |
| Ig heavy chain V-III region VH26 | P01764;P01768 | 3 | 1 | 4.35E-04 | 0.29 | |
| Ig kappa chain V-II region Cum | P01614;P01617 | 3 | 1 | 4.15E-03 | 2.14 | |
| Ig kappa chain V-II region RPMI 6410 | P06310;P01615;P01616 | 3 | 2 | 6.26E-03 | 0.34 | |
| Complement factor B (CFB) | P00751 | 5 | 5 | 8.16E-03 | 0.47 | 34, 35 |
| Fibrinogen gamma chain (FGG) | P02679 | 28 | 27 | 1.14E-02 | 0.50 | 33–36 |
| Ig mu heavy chain disease protein | P04220 | 25 | 2 | 1.62E-02 | 5.16 | |
Differentially expressed proteins in synovial fluid identified by LC-MS/MS. The table shows proteins of interest and common plasma proteins with significantly different levels of expression in low and high glucosinolate groups. Proteins were identified with >1 peptide, >2 fold change and controlled for 5% FDR. The number of peptides identified for each protein and the number of unique peptides for each protein are indicated. Proteins previously identified in the synovial fluid are referenced. Low glucosinolate n = 8, high glucosinolate n = 9. q-values are shown, significance level is q < 0.05. Mean fold change (FC) is given, calculated as peptide abundance in high/low glucosinolate group.