TABLE 2.
Comparative urovirulences of CFT073 and UPEC76 versus their respective ΔihaCFT073 derivatives in the mouse model of ascending UTI (competition experiments)
| Parent | Site cultured | Total no.c | No. (%)a with:
|
Pd | No. (%)b with:
|
Pd | ||
|---|---|---|---|---|---|---|---|---|
| Parent > ΔihaCFT073 mutant | ΔihaCFT073 mutant > parent | Parent only | ΔihaCFT073 mutant only | |||||
| CFT073nalR | Urine | 19 | 12 (63) | 2 (11) | <0.02 | 8 (42) | 0 (0) | <0.01 |
| Bladder | 19 | 16 (84) | 3 (16) | <0.01 | 2 (11) | 0 (0) | ||
| Right kidney | 19 | 11 (58) | 1 (5) | <0.01 | 2 (11) | 0 (0) | ||
| Left kidney | 19 | 11 (58) | 1 (5) | <0.01 | 4 (21) | 0 (0) | ||
| UPEC76 | Urine | 24c | 17 (71) | 5 (21) | 0.017 | 7 (29) | 1 (4) | 0.07 |
| Bladder | 30 | 18 (60) | 11 (37) | 6 (20) | 0 (0) | 0.03 | ||
| Right kidney | 30 | 19 (63) | 7 (23) | 0.03 | 8 (27) | 3 (10) | ||
| Left kidney | 30 | 16 (53) | 8 (27) | 9 (30) | 5 (17) | |||
a
Percentages do not sum to 100% in all instances because some cultures (included in denominators) yielded no growth. Comparative prevalence of the competing strains was assessed based on the CI, i.e., after adjusting the output ratio from that culture for the input ratio from the same experiment.
b
Percentages do not sum to 100% because some cultures yielded no growth or growth of both competing strains.
c
Urine was unavailable for six mice from the UPEC76 experiments.
d
P values (by McNemar's test; two tailed) are provided where P < 0.10.