Table 1.
Proteins involved in heat shock and their function are described.
| Summary of proteins involved in heat shock | ||
|---|---|---|
| Protein | Function | Reference |
| DnaK | DNA replication under heat shock; chaperone protein | (23) |
| DnaJ | Prevents aggregation of denatured proteins under hyperosmotic and heat shock | (23) |
| GrpE | Nucleotide exchange factor for DnaK; thermosensor | (23) |
| ClpP | Protease that degrades regulatory proteins | (23) |
| HscAB | Chaperone; maturation of iron–sulfur clusters during heat shock | (23) |
| σH and σ32 | Regulators heat shock response; controls envelope stress response to heat shock, acid stress | (27, 38–40) |
| FourU | Thermosensor; temperature-responsive RNA element | (40–46) |
| TlpA | Unknown but suggested to be a transcriptional regulator | (25, 47) |
| HtrA | Thermosensor endopeptidase; chaperone in the outer membrane and degrades misfolded proteins | (48–54) |
| RpoSa | General stress response sigma factor; DNA repair under stress | (55, 56) |
| FkpA | Involved in intracellular survival of macrophages | (57, 58) |
| SurAa | Outer membrane protein development and assembly; folding of proteins involved in transportation channels | (59–64) |
| H-NS | Virulence factor regulator under thermal changes | (65–70) |
aThose involved in both heat shock and virulence.