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. 2017 Jun 14;8:367. doi: 10.3389/fphar.2017.00367

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Copyright © 2017 Paech, Bouitbir and Krähenbühl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cellular and mitochondrial ROS production, cellular GSH content and SOD expression. (A) Mitochondrial ROS production by HepG2 cells after drug exposure for 48 h. (B) Production of H₂O₂ by HepG2 cells after drug exposure for 48 h. (C) mRNA expression of SOD1 and SOD2 in HepG2 cells after drug exposure for 48 h. (D) Protein expression of SOD1 and SOD2 in HepG2 cells after drug exposure for 48 h. (E) GSH content in HepG2 cells after drug exposure for 48 h. Basel GSH concentration of control incubations (0.1% DMSO) was 24.4 ± 6.0 μM. All data are expressed as fold change to control incubations containing 0.1% DMSO. Data represent the mean ± SEM of at least three independent experiments. ^∗p < 0.05, ^∗∗p < 0.01 or ^∗∗∗p < 0.001 versus DMSO control.