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. 2017 Jun 14;8:376. doi: 10.3389/fphar.2017.00376

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Copyright © 2017 Li, Li, Ren, Lv, Zhang, Xu, Wang, Yao, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The plasma concentration vs. time profiles of arctigenin in beagle dogs after sublingual administration (s.l) or intravenous injection (i.v) by arctigenin in different doses. (A,B) The different AG concentrations of beagle dogs’ plasma after i.h AG in 2.687, 5.374, or 10.748 μmol/dog. (C,D) The comparison between s.l and i.v of AG concentration. (E,F) The comparison between s.l and i.v of AG concentration at the dose of 5.374 μmol/dog. The results showed as normal (left) or semilogarithmic coordinates (right). (n = 6 per treatment group; results are presented as the mean ± SD).