Table 1.
Pharmacokinetic parameters of arctigenin (2.687 μmol/kg) after intravenous (i.v) and hypodermic injection (i.h) AG administrations in Wistar rats (n = 6 per treatment group, results were presented as Mean ± SD).
| Parameters | Units | i.h (dose) |
i.v (dose) |
|---|---|---|---|
| 2.687 μmol/kg | 2.687 μmol/kg | ||
| Cmax | μmol/L | 1.26 ± 0.3 | / |
| Tmax | Min | 15 ± 0 | / |
| AUC0-t | Min μmol/L | 77.39 ± 22.9 | 66.26 ± 18.7 |
| AUC0-∞ | Min μmol/L | 77.87 ± 24.67 | 67.87 ± 18.9 |
| MRT0-∞ | Min | 54.48 ± 14.04 | 39.6 ± 7.38 |
| MRT0-t | Min | 49.86 ± 15.36 | 24 ± 6.26 |
| Vd | L/kg | 5.8 ± 2.13 | 12.4 ± 4.52 |
| CL | L/min/kg | 0.035 ± 0.011 | 0.04 ± 0.014 |
| t1/2 | Min | 116.4 ± 21.72 | 217.8 ± 74.04 |
| F | 116% |