Table 9.

Metabolic effects of mouse LOX-1/OLR1 antibody 10 min exposure followed by 6 min exposure to Kalen high oxLDL on macrophages. Mean peak MAMP height changes and standard errors for each experimental condition during antibody exposure, oxLDL exposure, and recovery are shown. All p values are calculated based on peak height versus 10 min average basal value prior to exposure. Terms in bold are representative of p < 0.05, indicating statistical significance.

Mouse LOX-1/OLR1 antibody and oxLDL exposure
		Glucose (%)	Lactate (%)	Oxygen (%)	Acidification (%)
1 μg/mL		n = 3	n = 3	n = 3	n = 4
	Antibody exposure	20.1 ± 17.8	3.15 ± 0.6	43.2 ± 39.9	7.9 ± 7.7
		p = 0.9699	p = 0.0046	p = 0.3284	p = 0.4077
	oxLDL exposure	32.9 ± 34.3	5.1 ± 2.1	20.4 ± 13.3	5.27 ± 6.5
		p = 0.446	p = 0.0606	p = 0.1868	p = 0.5293
	Recovery	27.3 ± 44.0	6.61 ± 1.9	92.7 ± 56.1	29.7 ± 34.5
		p = 0.5972	p = 0.0192	p = 0.1594	p = 0.4217
10 μg/mL		n = 3	n = 4	n = 4	n = 2
	Antibody exposure	1.92 ± 11.5	3.55 ± 0.91	17.34 ± 9.8	1.72 ± 0.97
		p = 0.9584	p = 0.0109	p = 0.1785	p = 0.1754
	oxLDL exposure	14.8 ± 27.1	6.4 ± 0.99	10.8 ± 2.6	11.2 ± 4.2
		p = 0.7436	p = 0.0007	p = 0.1529	p = 0.0759
	Recovery	12.3 ± 38.1	9.9 ± 1.1	0.2 ± 1.4	9.64 ± 6.9
		p = 0.8174	p < 0.0001	p = 0.9758	p = 0.2568
50 μg/mL		n = 4	n = 3	n = 2	n = 2
	Antibody exposure	15.5 ± 20.8	5.7 ± 9.5	124.21 ± 124.2	4.7 ± 1.9
		p = 0.781	p = 0.5755	p = 0.391	p = 0.0995
	oxLDL exposure	14.0 ± 15.9	11.8 ± 8.9	141.9 ± 173.6	20.6 ± 10.9
		p = 0.7947	p = 0.2425	p = 0.4737	p = 0.1557
	Recovery	138.7 ± 104.2	1.1 ± 5.6	135.8 ± 166.9	40.2 ± 6.2
		p = 0.2679	p = 0.8496	p = 0.4754	p = 0.0076
100 μg/mL		n = 3	n = 3	n = 3	n = 2
	Antibody exposure	1.85 ± 6.7	0.67 ± 0.25	34.4 ± 10.2	1.05 ± 1.51
		p = 0.7939	p = 0.2218	p = 0.0203	p = 0.5369
	oxLDL exposure	8.56 ± 1.8	4.34 ± 2.4	30.4 ± 12.1	34.6 ± 30.1
		p = 0.0057	p = 0.1348	p = 0.0544	p = 0.3337
	Recovery	18.5 ± 1.9	2.06 ± 1.9	10.3 ± 8.1	57.2 ± 48.6
		p = 0.0002	p = 0.3377	p = 0.2633	p = 0.324