Figure 6.

Model for the regulation of neutrophil migration to a wound. (a) During homeostasis, neutrophils are retained in the caudal hematopoietic tissue by Cxcr4/Cxcl12. (b) After damage, the expression of Gcsf-Chr19 would increase and interact with its receptor, Gcsfr. Likewise, mRNA levels of Cxcl8b and Cxcr2 would increase, and both proteins would interact. Therefore, both signaling pathways would allow neutrophils to leave the caudal hematopoietic tissue and enter the bloodstream. Neutrophils would stay in circulation until sensing an unknown signal (probably Cxcl8b) in the endothelium, then leaving the blood vessel. Finally, in the interstitial tissue, Cxcl8a/Cxcr2 would guide neutrophils to the wound.