Table 3.

Results of CTLA4 polymorphisms and PBC.

SNP	Genetic model	Asian			Caucasian			Overall
		OR	95%CI	p	OR	95%CI	p	OR	95%CI	p
rs231775	G : A	1.47	1.27, 1.72	<0.0001	1.24	1.09, 1.42	0.001	1.32	1.19, 1.47	<0.0001
	GG : AA	2.10	1.55, 2.84	<0.0001	1.51	1.12, 2.04	0.006	1.72	1.37, 2.16	<0.0001
	GA : AA	1.39	1.08, 1.79	0.011	1.24	1.09, 1.42	0.001	1.27	1.13, 1.43	<0.0001
	(GG + GA) : AA	1.65	1.30, 2.10	<0.0001	1.31	1.16, 1.49	<0.0001	1.38	1.23, 1.54	<0.0001
	GG : (AA + GA)	1.66	1.40, 1.96	<0.0001	1.39	1.18, 1.65	<0.0001	1.52	1.35, 1.71	<0.0001
rs231725	A : G	1.39	1.22, 1.57	<0.0001	1.27	1.12, 1.44	<0.0001	1.33	1.22, 1.45	<0.0001
	AA : GG	1.92	1.47, 2.49	<0.0001	1.75	1.33, 2.29	<0.0001	1.83	1.52, 2.21	<0.0001
	GA : GG	1.38	1.07, 1.76	0.012	1.11	0.93, 1.33	0.236	1.20	1.04, 1.38	0.015
	(AA + GA) : GG	1.57	1.24, 1.99	<0.0001	1.23	1.04, 1.46	0.014	1.34	1.17, 1.53	<0.0001
	AA: (GG + GA)	1.52	1.27, 1.83	<0.0001	1.66	1.29, 2.14	<0.0001	1.57	1.35, 1.82	<0.0001
rs3087243	A : G	0.78	0.68, 0.89	<0.0001	0.83	0.76, 0.91	<0.0001	0.81	0.75, 0.88	<0.0001
	AA : GG	0.66	0.49, 0.90	0.008	0.70	0.58, 0.85	<0.0001	0.69	0.59, 0.81	<0.0001
	GA : GG	0.76	0.63, 0.91	0.003	0.90	0.68, 1.21	0.491	0.84	0.70, 1.00	0.051
	(AA + GA) : GG	0.74	0.62, 0.88	0.001	0.86	0.66, 1.11	0.250	0.80	0.68, 0.94	0.008
	AA : (GG + GA)	0.74	0.55, 1.00	0.050	0.78	0.66, 0.92	0.004	0.77	0.67, 0.89	0.001
rs5742909	T : C	0.87	0.70, 1.08	0.206	0.92	0.55, 1.55	0.766	0.89	0.68, 1.17	0.417
	TT : CC	0.90	0.51, 1.58	0.715	0.88	0.39, 1.99	0.762	0.89	0.56, 1.42	0.636
	TC : CC	0.84	0.64, 1.10	0.199	0.95	0.55, 1.64	0.846	0.90	0.67, 1.22	0.506
	(TT + TC) : CC	0.85	0.66, 1.09	0.200	0.93	0.53, 1.63	0.809	0.90	0.67, 1.20	0.463
	TT : (CC + TC)	0.93	0.53, 1.63	0.804	0.87	0.39, 1.97	0.743	0.91	0.58, 1.45	0.695

OR: odd ratio; 95%CI: 95% confidence interval; p: p value of Z-test for significance test of OR; using the Bonferroni correction, p < 0.0127 means statistically significant.